The shutdown is between Exit 100: PA 443 - PINE GROVE and Exit 90: PA 72 - LEBANON starting at 8:17 a.m. on Friday, July 15, PennDOT says.
The crash is fatal and involves a van and a tractor-trailer, according to Schuykill County emergency dispatchers.
It is unknown how many people were hurt or how long the road will remain shuttered.
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